[Neurolymphomatosis as initial manifestation of recurrence in lymphoma].

We present the case of a 71-year-old woman diagnosed with diffuse large B-cell non-Hodgkin lymphoma, stage IV-B, IPI 3, in complete remission after 6 cycles of rituximab-CHOP. Fivemonths after completing treatment the patient went to the Emergency Department for a picture of headache and diplopy of one month of evolution. During admission she present lumbosciatalgia refractory to pharmacologic treatment. LumbosacralMRwas performed showing no signs of lymphomatous disease (Fig. 1). CSF study demonstrated relapse of lymphoma in the CNS and intrathecal therapy was initiated. At the end of the treatment 18FFDG/PET-CT showed hypermetabolic foci in axillary, lumbar and pelvis regions compatible with nervous system tumoral involvement (neurolymphomatosis). In addition, hypermetabolic foci in thehumeral head and sacrumwere observed compatiblewith bone involvement by lymphoma (Fig. 2). Lymphatic infiltration of the peripheral nervous system (neurolymphomatosis) is a rare manifestation of non-Hodgkin